The primary educational objective of this FOA is to provide opportunities for eligible SBCs to submit NIH STTR grant applications to develop IDM STEM products that address student career choice and health and medicine topics for: (1) pre-kindergarten to grade 12 (P-12) students and teachers or (2) informal science education (ISE) audiences. The second educational objective is to inform the American public that their quality of health is defined by lifestyle. If this message is understood, people can begin to live longer and reduce the healthcare burden to society. Therefore, this FOA also encourages IDM STEM products that will increase public health literacy and stimulate behavioral changes towards a healthier lifestyle. The research objective of this FOA is the development of new educational products that will advance our understanding of how IDM STEM-based gaming can improve student learning. It is anticipated that increasing underserved and minority student achievement in STEM fields through IDM STEM resources will encourage these students to pursue health-related careers that will increase their economic and social opportunities. A diverse health care workforce will help to expand health care access for the underserved, foster research in neglected areas of societal need, and enrich the pool of managers and policymakers to meet the needs of a diverse populations. Types of applications submitted to this FOA may vary with the target audience, scientific content, educational purpose and method of delivery. IDM STEM products may include but are not limited to: game-based curricula, resources that promote attitude changes toward learning, new skills development, teamwork and group activities, public participation in scientific research (citizen science) projects, and behavioral changes in lifestyle and health. IDM STEM products designed to increase the number of underserved students, e.g., American Indian, Alaska Native, Pacific Islanders, African American, Hispanic, disabled, or otherwise underrepresented individuals considering careers in basic, behavioral or clinical research are encouraged. IDM STEM products may be designed for use in-classroom or out-of-classroom settings, e.g., as supplements to existing classroom curricula, for after-school science clubs, libraries, hospital waiting rooms and science museums. IDM products may target children in group settings or individually, with or without adult or teacher participation or supervision. The proposed project may use any IDM gaming technology or platform but the platform chosen must be accessible to the target group.